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President Donald Trump listens as Dr. Deborah Birx, the White House coronavirus response coordinator, speaks during a news briefing at the White House on Sunday.
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Debate heats up as Trump touts anti-malaria drug not yet officially approved for COVID-19

Patrick Semansky/Associated Press

Debate heats up as Trump touts anti-malaria drug not yet officially approved for COVID-19

WASHINGTON — President Donald Trump and members of his administration are growing emphatic in promoting an anti-malaria drug not yet officially approved for fighting COVID-19, even though scientists say more testing is needed before it’s proven safe and effective against the virus.

Trump trade adviser Peter Navarro promoted the drug, hydroxychloroquine, in television interviews Monday, a day after Mr. Trump publicly put his faith in the drug to lessen the toll of the coronavirus pandemic.

“What do I know, I’m not a doctor,” the president told reporters Sunday. “But I have common sense.”

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The administration’s public backing of the drug comes after a heated Situation Room meeting of the White House’s coronavirus task force Saturday, in which Mr. Navarro challenged the top U.S. infectious disease expert, Dr. Anthony Fauci, over his concerns about recommending the drug based only on unscientific anecdotal evidence.

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Mr. Navarro, who has no medical training, erupted at Dr. Fauci, raising his voice and claiming that the reports of studies he collected were enough to recommend the drug widely, according to a person familiar with the exchange who spoke on the condition of anonymity to describe the Situation Room blow-up.

Dr. Fauci has repeatedly said that current studies provide only anecdotal findings that the drug works. Mr. Navarro told CNN on Monday: “I would have two words for you: second opinion.”

Hydroxychloroquine is officially approved for treating malaria, rheumatoid arthritis and lupus — but not COVID-19. Small, preliminary studies have suggested it might help prevent the new coronavirus from entering cells and could possibly help patients clear the virus sooner. But even those small studies have shown mixed results.

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Some doctors are already prescribing the malaria drug to patients with COVID-19, a practice known as off-label prescribing. Research studies are now beginning to test if the drugs truly help COVID-19 patients, and the Food and Drug Administration has allowed the drugs into the national stockpile as an option for doctors to consider for patients who cannot get into one of the studies.

But the drug has major potential side effects, especially for the heart, and Dr. Fauci has said more testing is needed before it’s clear that the drug works against the virus and is safe for use.

Mr. Navarro told Fox News Channel’s “Fox & Friends” that doctors in New York hospitals are already giving out the drug to COVID-19 patients and that health care workers are taking it in hopes of being protected from infection. And while he acknowledged the Saturday debate with Dr. Fauci, he said the focus was on whether the administration should take 29 million doses of the drug in Federal Emergency Management Agency warehouses and send them to hard-hit cities.

“The media is trying to blow it up as a big big debate, but I can tell you that within the room the decision was a sound one, and it was unanimous,” Mr. Navarro said.

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Asked about his credentials for pushing the drug, Mr. Navarro cited his doctorate in social science.

“In the fog of war, we might take more risks than we otherwise would. And given the track record of the drug over many, many years in treating malaria, that there are side effects, but it’s been used a lot in lesser doses, the decisions’s been made by many doctors to prescribe it,” he said. “If it saves lives, that’s a beautiful thing ... I think history will judge who’s right on this debate. I’d bet on President Trump’s intuition on this one.”

Mr. Trump has been enthusiastically supporting the drug. He announced Sunday that his administration has amassed 29 million doses for distribution to hard-hit areas of the country.

“There’s a study out there that says people that have lupus haven’t been catching this virus,” Mr. Trump said. “You know, maybe it’s true, maybe it’s not. ... There’s also other studies ... that the malaria countries ... have very little of this virus.”

It was not clear what studies he was referring to, and he did not cite specifics or data.

Mr. Trump said he would likely take the drug. “I may take it. OK? I may take it. And I’ll have to ask my doctors about that, but I may take it.”

Administration officials say Mr. Trump’s embrace of the drug stems from his desire to provide “hope” for the American people as the death toll mounts — and as he looks to avoid political consequences from the outbreak.

Some limited studies have been conducted on the use of hydroxychloroquine and antibiotic azithromycin in concert to treat COVID-19, but they have not included critical control groups that scientists use to validate the conclusions.

A series of 11 patients in France found that an antibiotic-malaria drug combo did not improve how fast patients cleared the virus or their symptoms. Researchers in China reported that cough, pneumonia and fever seemed to improve sooner among 31 patients given hydroxychloroquine compared with 31 others who did not get the drug, but fewer people in the comparison group had cough or fevers to start with.

At least one other world leader has followed on Mr. Trump’s claims to promote the use of the drugs.

Brazil President Jair Bolsonaro has repeatedly touted the benefits of hydroxychloroquine and azithromycin. He claimed he heard reports of 100% effectiveness when administered in the correct dosages. He also zeroed tariffs for import of the drugs and has announced ramped-up chloroquine production.

On Sunday, he shared a video on social media of Mr. Trump’s personal attorney Rudy Giuliani interviewing a doctor who claimed he has successfully treated hundreds of coronavirus patients with the drugs.

Brazil’s health minister, Luiz Henrique Mandetta, who has led the nation’s virus response and endorsed broad isolation measures, said Friday that initial tests of chloroquine’s efficacy remain “fragile.” Still, he announced the government would broaden criteria for the drug’s use in “grave” cases. Previously, it had only authorized its use in “critical” cases.

Fringe media outlets, pro-Trump social media users and conservative pundits have pushed hydroxychloroquine as a miracle drug for weeks. Social media platforms have taken down false references from conservative personalities and politicians who claim hydroxychloroquine is an infallible method for treating COVID-19 patients.

Last week, Twitter and Facebook took the unprecedented step of removing video posts from Mr. Bolsonaro. He falsely stated in one that hydroxychloroquine was “working in all places” to treat coronavirus.

Twitter also removed a tweet from Mr. Giuliani in which he falsely asserted that the drug is “100 percent effective” in treating coronavirus. Mr. Giuliani has since made the same claim on Fox News.

For most people, the virus causes mild or moderate symptoms, such as fever and cough that clear up in two to three weeks. For some, especially older adults and people with existing health problems, it can cause more severe illness, including pneumonia, and death.

AP writers Marilynn Marchione, Amanda Seitz and David Biller contributed.

First Published: April 6, 2020, 9:29 p.m.

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